反应详情

0.24 moles (S)-(+)-3-hydroxy-butyric acid ethyl ester in 100 ml benzene are added to 0.07 moles anhydrous ZnCl2 while agitating and while excluding moisture. Subsequently, 0.72 moles SOCl2 are added, and the product is agitated at room temperature for two days. Then the reaction mixture is treated with saturated NaHClO3 solution. After separating off the aqueous phase, it is dried with Na2SO4. The solvent is distilled off, and the residue is fractionally distilled. One obtains (R)-(-)-chlorobutyric acid ethyl ester with a yield of 65 percent.

1. stirringthe product is agitated at room temperature for two days
2. customAfter separating off the aqueous phase, it
3. dry with materialis dried with Na2SO4
4. distillationThe solvent is distilled off
5. distillationthe residue is fractionally distilled