Potassium Hydroxide → HCID 136364557, compound

Participants

Reaction Steps

In an argon stream, 5 ml of ethanol was added to 175 mg (0.329 mM) of (-)-ethyl 3-[2-((S)-alpha-methoxybenzylcarbonyloxy)ethyl]-6-methyl-4-(3-nitrophenyl)-4,7-dihydroisothiazolo[5,4-b]pyridine-5-carboxylate obtained in Example 55 to form a solution. While the solution was cooled with ice-sodium chloride, 7 ml of a 7% aqueous solution of potassium hydroxide was added, and the mixture was stirred at the above temperature for 5 minutes. The reaction mixture was extracted with ethyl acetate. The ethyl acetate layer was washed successively with a saturated aqueous solution of sodium hydrogen carbonate, water and a saturated aqueous solution of sodium chloride, and then dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give (-)-ethyl 3-(2-hydroxyethyl)-6-methyl-4-(3-nitrophenyl)-4,7-dihydroisothiazolo[5,4-b]pyridine-5-carboxylate quantitatively.

Provenance & Evidence