反应详情

A mixture of 3.51 g (0.014 mol) 2-[(3-hydroxyphenoxy)methyl]quinoline, 2.04 g (0.14 mol) 5-(3-chloropropyl)tetrazole and 2 g (0.036 mol) KOH in 5 ml water and 50 ml ethanol is heated over a steam bath for a period of 3 hours. Reaction mixture is concentrated to dryness and slurried into water and extracted with methylene chloride. The methylene chloride extract is washed with water, dried over MgSO4 and concentrated under reduced pressure to obtain solid which is passed through a silica gel column using hexane/ethyl acetate (55:45) as eluent. Evaporation of eluent gives 5-[3-(3-(2-quinolylmethyloxy)phenoxy)propyl]tetrazole (M.P. 147°-149° C.).

1. temperatureis heated over a steam bath for a period of 3 hours
2. customReaction mixture
3. concentrationis concentrated to dryness
4. extractionextracted with methylene chloride
5. extractionThe methylene chloride extract
6. washis washed with water
7. dry with materialdried over MgSO4
8. concentrationconcentrated under reduced pressure
9. customto obtain solid which
10. customEvaporation of eluent