Sodium Hydroxide → HCID 178419996, compound

Participants

Reaction Steps

A mixture of 9.8 g (0.032 mol) of 3-[4-(2-quinolylmethyloxy)phenoxy]propionitrile, 6.36 g of sodium azide and 5.28 g of ammonium chloride is heated with 30 ml of dry dimethylformamide at 140° C. for 20 hours. The reaction mixture is poured onto ice, basified with 1N sodium hydroxide and extracted 2 times with ethyl acetate. The aqueous fraction is acidified with acetic acid. The product is filtered and washed with water. The crude product is crystallized from acetonitrile to give 5-[2-(4-(2-quinolylmethyloxy)phenoxy)ethyl]tetrazole.

Provenance & Evidence