Sodium Hydroxide → HCID 178441992, compound

Participants

Reaction Steps

A mixture of 5.9 g of 4-(3-hydroxyphenoxy)valeronitrile, 6.13 g of sodium azide and 5.0 g of ammonium chloride is heated with 30 ml of dry dimethylformamide at 140° C. for 20 hours. The reaction mixture is poured into ice, basified with 1N sodium hyroxide and extracted 2 times with warm ethyl acetate. The aqueous fraction is acidified with acetic acid. The product is filtered and washed with water to give crude product. Crystallization from ethyl acetate gives pure product which is used directly in the next step.

Provenance & Evidence