Sodium Hydroxide → HCID 178419997, compound

Participants

Reaction Steps

A mixture of 8.0 g of 4-[4-(2-quinolylmethyloxy)phenoxy]butyronitrile, 4.9 g of sodium azide and 4.0 g of ammonium chloride is heated with 25 ml of dry dimethylformamide at 140° C. for 20 hours. The reaction mixture is poured into ice, basified with 1N sodium hydroxide and extracted 2 times with warm ethyl acetate. The aqueous fraction is acidified with acetic acid. The product is filtered and washed with water to give 6.6 g of crude product. Crystallization from ethyl acetate gives 4.2 g of the light tan product, M.P. 158°-160° C.,

Provenance & Evidence