Water → HCID 19844666, compound

Participants

Reaction Steps

To a mixture containing 10.6 g of 1-[2-[1-(2,5-dimethylphenyl)-1-phenylpropoxy]ethyl]piperazine and 4.6 g of anhydrous, powdered potassium carbonate in 90 ml of anhydrous benzene, 3.6 g of allyl bromide dissolved in 10 ml of benzene are dropped while mild refluxing, then the reaction mixture is boiled for one additional hour. After cooling down, water is added to the mixture, the organic phase is separated, washed with water until neutral, dried over anhydrous sodium sulfate and evaporated under reduced pressure. The anhydrous ethanolic solution of the evaporation residue is treated with an ethanolic fumaric acid solution. The solid precipitate is recrystallized from methanol to give the aimed dihydrogen fumarate, m.p. 202°-204° C.

Provenance & Evidence