Thionyl Chloride → 2-Chloro-4,5-difluoro-3-methylbenzoyl chloride

HRID 2351891Notes

Reaction equation

HRID 2351891 reaction equation
[Cl:1][C:2]1[C:10]([CH3:11])=[C:9]([F:12])[C:8]([F:13])=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:16])=O>>[Cl:1][C:2]1[C:10]([CH3:11])=[C:9]([F:12])[C:8]([F:13])=[CH:7][C:3]=1[C:4]([Cl:16])=[O:5]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 156318242-Chloro-4,5-difluoro-3-methylbenzoic acid

Product 1

HCID 156318252-Chloro-4,5-difluoro-3-methylbenzoyl chloride

Procedure

To 2-chloro-4,5-difluoro-3-methylbenzoic acid (3.1 g) is added thionyl chloride (6 ml), and the mixture is reflexed for one hour. The mixture is concentrated under reduced pressure to give 2-chloro-4,5-difluoro-3-methylbenzoyl chloride (3.3 g).

Workup

  1. concentrationThe mixture is concentrated under reduced pressure

Sources & evidence

ORD record
ord-32ee44465e1c4098b2ece3146b1dc46b
Source dataset
uspto-grants-1989_10
Patent number
US04874764

Reaction notes

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