Potassium Carbonate → HCID 14720311, compound

Participants

Reaction Steps

A 3.5 g. portion of 3-[1-(4-chlorophenylamino)ethyl]pyridine was dissolved in dichloromethane and 2.7 g. of potassium carbonate and 2.9 g. of dimethylsulfamoyl chloride were added. The mixture was stirred at ambient temperature for 3 days, and was then diluted with 25 ml. of additional dichloromethane and was extracted with water. The organic layer was dried over magnesium sulfate and evaporated to an oil, which was taken up in dichloromethane and chromatographed over silica gel, eluting with chloroform. The product-containing fractions were combined and evaporated to obtain about 0.3 g. of the desired product.

Provenance & Evidence