Potassium Carbonate → HCID 14720324, compound

Participants

Reaction Steps

A 10 g. portion of 3-(2-methylphenylaminomethyl)pyridine was dissolved in 100 ml. of dichloromethane, and 10 g. of potassium carbonate and 8 g. of methanesulfonyl chloride were added. The mixture was stirred at ambient temperature for 3 days, and was then diluted with 200 ml. of dichloromethane and extracted twice with 100 ml. portions of water. The organic phase was dried over magnesium sulfate and evaporated to an oil, which was chromatographed over silica gel with 1:4 acetone:toluene. The product-containing fractions were combined and evaporated, and the residue solidified upon standing and was recrystallized from hot diethyl ether to obtain 2.9 g. of the desired product, m.p. 97°-98°.

Provenance & Evidence