Potassium Carbonate → HCID 14720326, compound

Participants

Reaction Steps

A 4.7 g. portion of 4-(2,4-difluorophenylaminomethyl)pyridine was dissolved in 15 ml. of chloroform, and 4.1 g. of potassium carbonate was added, followed by 2.3 ml. of methanesulfonyl chloride. The mixture was stirred under reflux overnight, and then for several days at ambient temperature. It was then diluted with 20 ml. of dichloromethane and 20 ml. of aqueous sodium bicarbonate, and 5 ml. of 2N sodium hydroxide was added. The organic phase was then washed with aqueous sodium bicarbonate, dried and evaporated. The residue was dissolved in dichloromethane and chromatographed over silica gel, to obtain 0.5 g. of impure product, which was triturated with diethyl ether to obtain 0.29 g. of the desired product, m.p. 101°-105°.

Provenance & Evidence