Potassium Carbonate → N-(2,4-difluorophenyl)-N',N'-dimethyl-N-(pyridin-3-ylmethyl)sulfamide

Participants

Reaction Steps

A 3.3 g. portion of 3-(2,4-difluorophenylaminomethyl)pyridine was dissolved in 15 ml. of dichloromethane, and 2.8 g. of potassium carbonate and 3.6 g. of dimethylsulfamoyl chloride were added. The mixture was stirred at ambient temperature for several days, and was then stirred under reflux for 4 hours. The mixture was then cooled, and extracted with 20 ml. of aqueous sodium bicarbonate and with 20 ml. of water, and was dried and evaporated to an oil. The oil was dissolved in dichloromethane and chromatographed over silica gel, eluting with 9:1 dichloromethane:ethyl acetate to obtain 2.1 g. of the desired product.

Provenance & Evidence