Potassium Carbonate → HCID 14720340, compound

Participants

Reaction Steps

A 6 g. portion of 3-(2-fluorophenylaminomethyl)pyridine was dissolved in 50 ml. of acetone, and 5 g. of potassium carbonate and 5 g. of methanesulfonyl chloride were added. The mixture was stirred at ambient temperature overnight, and then under reflux for 6 hours. The mixture was cooled and filtered, and the filtrate was concentrated under vacuum to obtain 7.4 g. of an oil, which was chromatographed on silica gel, eluting with 1:4 acetone:toluene. Combination of the product-containing fractions and evaporation gave 9.7 g. of the desired product, m.p. 120°.

Provenance & Evidence