Water → HCID 135464214, compound

HRID 2352011Notes

Reaction equation

HRID 2352011 reaction equation
[Br:1]N1C(=O)CCC1=O.[Cl:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][N:17]2[CH:25]=[N:24][C:23]3[C:22](=[O:26])[NH:21][C:20]([NH2:27])=[N:19][C:18]2=3)=[CH:12][CH:11]=1.O>C(O)(=O)C>[Br:1][C:25]1[N:17]([CH2:16][C:13]2[CH:14]=[CH:15][C:10]([Cl:9])=[CH:11][CH:12]=2)[C:18]2[N:19]=[C:20]([NH2:27])[NH:21][C:22](=[O:26])[C:23]=2[N:24]=1

Participants

5

Reactant 3

HCID 962WaterHCID 67184N-bromobutanimideHCID 1354313602-Amino-9-[(4-chlorophenyl)methyl]-3,9-dihydro-6H-purin-6-one

Product 1

HCID 135464214HCID 135464214, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

N-Bromosuccinimide (1.3 g, 7.3 mmol) is added to a suspension of 9-(4-chlorophenyl)methylguanine (1.5 g; 5.4 mmol), Example 3, in glacial acetic acid (100 ml) and the mixture is stirred for 20 hours at room temperature. The solution is poured into water (400 ml) and the resulting precipitate is filtered, washed with water and methanol and dried. Yield: 1.0 g; mp>300° C.

Workup

  1. filtrationthe resulting precipitate is filtered
  2. washwashed with water and methanol
  3. customdried

Sources & evidence

ORD record
ord-f54c52d3b4ce48ec8c488cdbd6dcb770
Source dataset
uspto-grants-1989_10
Patent number
US04874862

Reaction notes

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