反应详情

To a solution of 3.49 g of methyl 4-[4-(1-hydroxy-2-Phenylethyl)phenyl]butyrate in 17 ml of benzene, 1.10 ml of thionyl chloride was added dropwise under ice-cooling, and then stirring was continued at room temperature for 1.5 hours. The reaction solvent was removed under reduced pressure, and the residue was dissolved in ether. The ether layer was washed with water and dried, and then the solvent was removed under reduced pressure to yield 3.30 g of pale yellow oil.

1. temperaturecooling
2. customThe reaction solvent was removed under reduced pressure
3. dissolutionthe residue was dissolved in ether
4. washThe ether layer was washed with water
5. customdried
6. customthe solvent was removed under reduced pressure