Thionyl Chloride → HCID 10543482, compound

HRID 235202Notes

Reaction equation

HRID 235202 reaction equation
O[CH:2]([C:10]1[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][CH2:18][C:19]([O:21][CH3:22])=[O:20])=[CH:12][CH:11]=1)[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.S(Cl)([Cl:25])=O>C1C=CC=CC=1>[Cl:25][CH:2]([C:10]1[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][CH2:18][C:19]([O:21][CH3:22])=[O:20])=[CH:12][CH:11]=1)[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 10756510HCID 10756510, compound

Product 1

HCID 10543482HCID 10543482, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To a solution of 3.49 g of methyl 4-[4-(1-hydroxy-2-Phenylethyl)phenyl]butyrate in 17 ml of benzene, 1.10 ml of thionyl chloride was added dropwise under ice-cooling, and then stirring was continued at room temperature for 1.5 hours. The reaction solvent was removed under reduced pressure, and the residue was dissolved in ether. The ether layer was washed with water and dried, and then the solvent was removed under reduced pressure to yield 3.30 g of pale yellow oil.

Workup

  1. temperaturecooling
  2. customThe reaction solvent was removed under reduced pressure
  3. dissolutionthe residue was dissolved in ether
  4. washThe ether layer was washed with water
  5. customdried
  6. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-a1981cf088524d3e906f77ee928e6c61
Source dataset
uspto-grants-1997_01
Patent number
US05597848

Reaction notes

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