HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl 2,3-dihydro-1H-pyrrolizine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 2,3-Dihydro-1h-pyrrolizine-1-carboxylic acid | HCID 12795105 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | Methyl 2,3-dihydro-1H-pyrrolizine-1-carboxylate | HCID 12795075 | — |
Reaction Steps
2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid is dissolved in methanol containing a small amount of concentrated hydrochloric acid. The resulting solution is heated to reflux, and then cooled. The title compound is isolated by rotary evaporation of the solvent under reduced pressure, and may be purified by chromatography on silica gel with hexane/ethyl acetate as eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04874871 |
| Source dataset | uspto-grants-1989_10 |
| ORD ID | ord-586d422b14554575a5537722250183b1 |
| Source note | uspto-grants-1989_10 |