Hippuric Acid → 2-Phenyl-1,3-oxazol-5-one

HRID 2352043Notes

Reaction equation

HRID 2352043 reaction equation
[C:1]([OH:13])(=[O:12])[CH2:2][NH:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=O.C(OC(=O)C)(=O)C>>[C:6]1([CH:4]2[N:3]=[CH:2][C:1](=[O:12])[O:13]2)[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 464Hippuric AcidHCID 7918Acetic Anhydride

Product 1

HCID 532492532-Phenyl-1,3-oxazol-5-one

Procedure

The title compound was prepared by the dehydration of hippuric acid with acetic anhydride according to the procedure of Bullerwell and Lawson, [J. Chem. Soc. (1952), 1350], mp 91.5°-93.5° C. (lit. 91° C).

Sources & evidence

ORD record
ord-64311d807a274fffaed2a0624b8f8ca9
Source dataset
uspto-grants-1989_10
Patent number
US04874876

Reaction notes

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