Triethylamine → HCID 86743465, compound

Participants

Reaction Steps

In a small autoclave, 1.15 g of 1,1-diethyl-3-(2-iodo-1-propyl-6-methyl-8α-ergolinyl)urea is heated under argon for 3 hours to a bath temperature of 115° C. in 10 ml of dimethylformamide with 10 ml of triethylamine, 53.5 mg of triorthotolylphosphine, 39.4 mg of palladium(II) chloride and 1.34 ml of vinyltrimethylsilane. After evaporation, the mixture is distributed in methylene chloride/sodium bicarbonate solution. The organic phase is evaporated and chromatographed over silica gel with ethyl acetate: ethanol=3:1 as the eluent, thus obtaining 218 mg of 1,1-diethyl-3-(2-trimethylsilylvinyl-1-propyl-6-methyl-8α-ergolinyl)urea and 230 mg of 1,1-diethy-3-(2-vinyl-1-propyl-6-methyl-8α-ergolinyl)urea as oils.

Provenance & Evidence