HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 86743465, compound → HCID 86743466, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 86743465 | HCID 86743465 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 86743466 | HCID 86743466 | 43.1% |
Reaction Steps
At room temperature and under hydrogen normal pressure, 150 mg of 1,1-diethyl-3-(2-vinyl-1-propyl-6-methyl-8α-ergolinyl)urea is hydrogenated in 20 ml of ethanol with 0.1 g of Raney nickel (B 115 Z). After the catalyst has been filtered off over kieselguhr, evaporation of the filtrate, and chromatography over silica gel with toluene:ethanol:water=80:20:1 as the eluent, 65 mg of 1,1-diethyl-3-(2-ethyl-1-propyl-6-methyl-8α-ergolinyl)urea is obtained as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04874768 |
| Source dataset | uspto-grants-1989_10 |
| ORD ID | ord-23be734dc419415da2c8bbdef6bb4b9d |
| Source note | uspto-grants-1989_10 |