Phenylacetone → HCID 70381759, compound

Participants

Reaction Conditions

Reaction Steps

Analogously to Example 5, 4 g. (22.7 mmole) 6-amino-3,3-dimethylindolin-2-one are diazotised and reduced. Subsequently, 3 g. (22.3 mole) phenylacetone are added thereto and the reaction mixture further stirred for 18 hours at 25° C. The oil which separates out is shaken out several times with methylene chloride, evaporated and the residue worked up with cyclohexane and filtered off with suction. The solid residue is again dissolved in methylene chloride, washed twice with aqueous sodium hydrogen carbonate solution and once with water, dried with anhydrous sodium sulphate with the addition of charcoal and crystallised from methylene chloride. Yield 1.25 g. (19% of theory); m.p. 233°-235° C.

Provenance & Evidence