HCID 15617483, compound → HCID 19817954, compound

HRID 2352111Notes

Reaction equation

HRID 2352111 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]C2C=C(C=CC=2)C=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:23]([CH2:27][CH2:28][S:29][CH:30]([C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][C:38]=1CCCCCCCCC1C=CC=CC=1)[CH:31]([OH:36])[C:32]([O:34]C)=[O:33])([O:25]C)=[O:24]>>[C:23]([CH2:27][CH2:28][S:29][CH:30]([C:37]1[CH:38]=[CH:39][CH:40]=[C:41]([CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH:42]=1)[CH:31]([OH:36])[C:32]([OH:34])=[O:33])([OH:25])=[O:24]

Participants

3

Reactant 2

HCID 15617483HCID 15617483, compoundHCID 19817986HCID 19817986, compound

Product 1

HCID 19817954HCID 19817954, compound

Procedure

Similarly, following the procedure of Example 7(b), 3-bromobenzaldehyde was reacted with 1-phenylocta-1,7-diyne to yield 3-(8-phenyl-1,7-octadiynyl)benzaldehyde which was reduced to 3-(8phenyloctyl)benzaldehyde and the latter was reacted as described in Example 35(a), (b) and (c) to give 3-(2-carboxyethylthio)-3-[3-(8phenyloctyl)phenyl]-2-hydroxypropanoic acid, dipotassium salt, hydrate as a mixture of isomers, -log KB value 6.2.

Workup

  1. customthe latter was reacted

Sources & evidence

ORD record
ord-5a5b59bdafbb4540ae6019c75e14bc42
Source dataset
uspto-grants-1989_10
Patent number
US04874792

Reaction notes

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