Methanesulfonic Acid → HCID 23044834, compound

Participants

Reaction Steps

1.9 g of 3-phenyl-pyridin-2-ylsulfonylsulfonamide and 2.2 g of N-(4,6-dimethoxy-pyrimidin-2-yl)-phenylcarbamat are dispersed in 40 ml of acetonitrile. A solution of 1.2 ml 1,8-diazabicyclo[5.4.0]undec-7-ene in 5 ml of acetonitrile are added dropwise, whereby a clear solution is obtained. This reaction solution is kept at room temperature for 16 hours. Then 0.7 ml of methanesulfonic acid and subsequently 15 ml of ice-water are added. A colourless percipitate is formed, which is collected, washed with water and dried. The separated precipitate is treated with ether and dried, yielding 3.2 g of N-(3-phenyl-pyridin-2-ylsulfonyl)-N'-(4,6-dimethoxypyrimidin-2-yl) urea, having a melting point of 181° C. with decomposition.

Provenance & Evidence