Ethyl bromoacetate → HCID 14347186, compound

HRID 2352171Notes

Reaction equation

HRID 2352171 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:12]=[CH:11][N:10]=[C:9]([NH:13][C:14]3[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=3)[N:8]=2)=[CH:3][CH:2]=1.[CH3:21][CH2:22][O:23][C:24]([CH2:26]Br)=[O:25]>>[N:1]1[CH:2]=[CH:3][C:4]([C:7]2[CH:12]=[CH:11][N:10]=[C:9]([NH:13][C:14]3[CH:19]=[CH:18][C:17]([O:20][CH2:26][C:24]([O:23][CH2:22][CH3:21])=[O:25])=[CH:16][CH:15]=3)[N:8]=2)=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 7748Ethyl bromoacetateHCID 135804947HCID 135804947, compound

Product 1

HCID 14347186HCID 14347186, compound

Procedure

A mixture of 5.58 g of 4-[[4-(4-pyridinyl)-2-pyrimidinyl]amino]phenol was reacted with ethyl bromo acetate as described in Example 255, giving 1.8 g of the desired product as yellow crystals, mp 109°-111° C.

Sources & evidence

ORD record
ord-d7bcfd4fcecd4652a7f5d61bfde17ec7
Source dataset
uspto-grants-1989_10
Patent number
US04876252

Reaction notes

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