Dichloromethane → HCID 14346988, compound

HRID 2352179Notes

Reaction equation

HRID 2352179 reaction equation
[C:1]1([NH:7][C:8]2[N:13]=[C:12]([C:14]3[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=3)[CH:11]=[CH:10][N:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:20]CCl>>[ClH:20].[ClH:20].[C:1]1([NH:7][C:8]2[N:13]=[C:12]([C:14]3[CH:15]=[CH:16][N:17]=[CH:18][CH:19]=3)[CH:11]=[CH:10][N:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 6344Dichloromethane2×HCID 14346985HCID 14346985, compound

Product 1

HCID 14346988HCID 14346988, compound

Procedure

A 2.0 g amount of N-phenyl-4-(4-pyridinyl)-2-pyrimidinamine was dissolved in 70 ml of dichloromethane with warming. The solution was cooled to room temperature, then hydrogen chloride gas was bubbled in to give a brick red precipitate. The mixture became very thick and more dichloromethane was added. The precipitate was collected, air dried, then dried in vacuo and gave 2.63 g of the desired product as red-orange crystals, mp 259°-262° C.

Workup

  1. temperaturewith warming
  2. customhydrogen chloride gas was bubbled in
  3. customto give a brick red precipitate
  4. customThe precipitate was collected
  5. customair dried
  6. customdried in vacuo

Sources & evidence

ORD record
ord-f812e9d3d5d146e1a949a90f90fde73e
Source dataset
uspto-grants-1989_10
Patent number
US04876252

Reaction notes

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