1-Chloroethyl chloroformate → 5-hydroxy-12-(alpha-chloroethoxycarbonyl)-12H-benzo[a]phenothiazine

Participants

Reaction Steps

A mixture of 5-hydroxy-12H-benzo[a]phenothiazine (5 g) and α-chloroethyl chloroformate (10 g) in tetrahydrofuran (20 ml) was refluxed for 9 hours, then the volatile components were evaporated away and the residue chromatographed on a column of silica gel, eluting with a 1:9 ethyl acetate-hexane mixture to afford the title compound (4 g) as an oil.

Provenance & Evidence