HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylenediamine → N-(3,5-Difluorobenzyl)ethylenediamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylenediamine | HCID 3301 | — |
| Reactant | N-Benzylethylenediamine | HCID 77801 | — |
| Reactant | 3,5-Difluorobenzaldehyde | HCID 588160 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-(3,5-Difluorobenzyl)ethylenediamine | HCID 14653371 | 55% |
Reaction Steps
At 16.77 g (0.118 mol) quantity of 3,5-difluorobenzaldehyde was treated with 50 ml ethylenediamine and 4.47 g (0.118 mol) sodium borohydride in 500 ml methanol by the method prescribed for N-benzylethylenediamine (Example 1) to give 12.0 g (55% yield) of desired product, b.p. 90°-92° C. at 199.98-226.65 Nm-2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04876266 |
| Source dataset | uspto-grants-1989_10 |
| ORD ID | ord-bc21e46a188f4b1785cd78c921e72997 |
| Source note | uspto-grants-1989_10 |