Water → HCID 14653376, compound

Participants

Reaction Conditions

Reaction Steps

1-(3,5-difluorobenzyl)-2-mercaptoimidazoline, prepared as in example 8, and potassium hydroxide in equimolar proportions in dimethylformamide and water are stirred under argon at ambient temperature, and one mole of methyl-3-bromopropionate is added. The reaction mixture is heated at 95° C. overnight, cooled, and extracted three times with ether, and the combined ether extracts are concentrated. Purification by flash chromatography on silica gel gives 2-(2-carbomethoxyethylthio)-1-(3,5-difluorobenzyl)imidazoline.

Provenance & Evidence