HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2352245Generated: October 31, 2026
Formaldehyde → 4-(4-Methylsulfonylaminobenzoyl)-1-[2-(2-quinoxalinyl)ethyl]piperidine
https://huagongshe.com/reaction/2352245
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-Methylquinoxaline | HCID 23686 | — |
| Reactant | N-[4-(piperidine-4-carbonyl)-phenyl]methanesulfonamide hydrochloride | HCID 14130042 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(4-Methylsulfonylaminobenzoyl)-1-[2-(2-quinoxalinyl)ethyl]piperidine | HCID 14130055 | 5% |
Reaction Steps
5.0 g (15.7 mmol) of 4-(4-methylsulfonylaminobenzoyl)piperidine hydrochloride was suspended in 5 ml of ethanol. 2.49 g of 2-methylquinoxaline and 7.0 ml of formalin were added to the suspension and the mixture was stirred at 90° C. for 1 h. After cooling, the mixture was neutralized with a 20% aqueous sodium hydroxide solution and the formed crystals were recrystallized from ethyl acetate to obtain 0.32 g (yield: 5%) of the intended compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04876262 |
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| Source dataset | uspto-grants-1989_10 |
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| ORD ID | ord-78f913c455f748fb9002fcbf7e5fe320 |
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| Source note | uspto-grants-1989_10 |
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