Sodium Carbonate → HCID 70385996, compound

HRID 2352308Notes

Reaction equation

HRID 2352308 reaction equation
C(OC(OCC)[CH:5]([N:8]1[C:12](=[O:13])[C:11]2=[CH:14][CH:15]=[CH:16][CH:17]=[C:10]2[C:9]1=[O:18])[CH2:6][CH3:7])C.[NH:22]([C:24]1[CH:29]=[CH:28][C:27]([S:30]([NH:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)(=[O:32])=[O:31])=[CH:26][CH:25]=1)[NH2:23].[C:40]([O-])([O-])=O.[Na+].[Na+]>C(O)(=O)C>[O:13]=[C:12]1[C:11]2[C:10](=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:9](=[O:18])[N:8]1[CH2:5][CH2:6][CH2:7][CH:40]=[N:23][NH:22][C:24]1[CH:29]=[CH:28][C:27]([S:30]([NH:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)(=[O:31])=[O:32])=[CH:26][CH:25]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 19844126HCID 19844126, compoundHCID 19844132HCID 19844132, compound

Product 1

HCID 70385996HCID 70385996, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Finely-divided phthalimidobutyraldehyde diethyl acetal (0.5 g) was added to a stirred solution of 4-hydrazino-N-phenyl-benzenesulphonamide (0.5 g) in 25% aqueous acetic acid (50 ml). After 30 min, the solution was basified (Na2CO3) and extracted with ethyl acetate (2×50 ml). The combined organic extracts were dried (MgSO4) and evaporated in vacuo to give an oil which was purified by flash chromatography eluted with ether to give the title compound as a solid (0.3 g) m.p. 126°-129°.

Workup

  1. extractionextracted with ethyl acetate (2×50 ml)
  2. dry with materialThe combined organic extracts were dried (MgSO4)
  3. customevaporated in vacuo
  4. customto give an oil which
  5. customwas purified by flash chromatography
  6. washeluted with ether

Sources & evidence

ORD record
ord-6441a4644152411d84654b37a297f483
Source dataset
uspto-grants-1989_10
Patent number
US04876267

Reaction notes

Loading…