Benzyl chloroformate → HCID 53766944, compound

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Reaction Steps

Benzyl chloroformate (1.55 ml) was added portionwise to a stirred solution of the product of Example 4 (4.3 g) in a mixture of ethyl acetate (100 ml) and sodium carbonate (2 N, 100 ml) and the resulting mixture stirred at room temperature for 1 h. The aqueous layer was extracted with ethyl acetate (100 ml), the organic extracts combined, washed with hydrochloric acid (1 N, 100 ml), sodium carbonate (2 N, 100 ml) dried (MgSO4) and evaporated in vacuo to give an oil. The oil was purified by flash chromatography eluted with chloroform:methanol (19:1) to give the title compound as a foam which collapsed to a gum (2.4 g) T.l.c. Silica, Chloroform-methanol (19:1) det. u.v.+CeIVRf 0.34

Provenance & Evidence