HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → (E)-4-Fluorocinnamoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Fluorocinnamic acid | HCID 1530234 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | (E)-4-Fluorocinnamoyl chloride | HCID 5706471 | 105.3% |
Reaction Steps
A mixture of 15.0 g. (0.09 mole) of trans-4-fluorocinnamic acid (Compound LXXVI) and 30 ml. (0.41 mole) of thionyl chloride in 100 ml. of toluene is stirred at 70° C. for 18 hours, and the solvent is evaporated at reduced pressure to obtain the crude product (17.5 g. (>100%)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04876280 |
| Source dataset | uspto-grants-1989_10 |
| ORD ID | ord-776ffac4160a49d59cd8051d63e04376 |
| Source note | uspto-grants-1989_10 |