Hydrogen Bromide → HCID 67822483, compound

Participants

Reaction Steps

cis-5-Methoxy-1-methyl-2-(N-n-pentyl-N-n-propyl-amino) tetralin hydrochloride (500 mg; 1.5 mmol) was heated in aqueous 48% HBr (3 ml) for 2 hours at 120° C. under N2. The mixture was evaporated and the residue was made alkaline with diluted NaHCO3 and extracted 3 times with ether. After drying (Na2SO4) and evaporation the product was precipitated as hydrochloride salt. Yield: 290 mg (60%) NMR (CDCl3), δ0.86 (t, 6H) δ1.17 (d, 3H), δ3.23-0.60 (m, 27H) δ5.36 (s, 1H phenolic) δ6.90 (m, 3H), MS (70 eV) m/z 289 (33%), 161 (100%), 232 (82%).

Provenance & Evidence