Diethyl Ether → HCID 14675603, compound

Participants

Reaction Steps

To a suspension of R-phenylephrine (10.0 g, 59.8 mmol) in diethyl ether (200 ml) with triethylamine (4 drops) is added ethyl isocyanate (4.25 g, 59.8 mmol) in diethyl ether (50 ml). The reaction is allowed to stir overnight at room temperature. A white suspension forms which is decanted from the precipitated gum, filtered and dried giving 3.0 g (21% yield) of product, m.p. 102°-105° C.

Provenance & Evidence