Ethyl Bromide → HCID 19795531, compound

Participants

Reaction Steps

The 1-ethyl-3-methyl-6-methoxyindol used is prepared as follows: 4.6 g of 3-methyl-6-methoxyindole [Chem. ber. 98, 1727 (1965)] are presented in 29 ml of dimethyl sulfoxide. 6.6 ml of 10n aqueous KOH are then added, and 3.25 g of ethyl bromide are added dropwise at 20° C. in the course of 30'. 1 hour later the reaction mixture is poured onto water and extracted with toluene. Chromatography over silica gel (hexane/ether 5:1) gives 3.9 g of 1-ethyl-3-methyl-6-methoxyindol in the form of an oil.

Provenance & Evidence