Nitric Acid → HCID 178491819, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 2-(2-Fluoro-5-methoxyphenyl)-4,6-dihydroxypyrimidine (12 g) in 35 mL of acetic acid is added 12 mL of 90% nitric acid and the mixture is heated at 50° C. for 45 min. The reaction mixture is diluted with 150 mL of water and the product is collected, washed with water and ethanol and oven dried to afford 2-(2-Fluoro-5-methoxyphenyl)-5 -nitro-4,6-dihydroxy-pyrimidine as a pink solid.

Provenance & Evidence