HCID 14819147, compound → HCID 14819161, compound

Participants

Reaction Steps

Dissolved in 50 ml of methanol was 3.80 g of Isomer B of N-(2-oxo-5-hexyl-3-tetrahydrofuranyl)-L-alanyl-L-proline benzyl ester (Compound 7). Thereafter, 0.40 g of 10% palladium-charcoal was added and the reaction mixture was hydrogenated at room temperature and normal pressure for 2 hours. The palladium-charcoal was then filtered off and the filtrate was distilled under reduced pressure to obtain as white powder 2.80 g of N-(2-oxo-5-hexyl-3-tetrahydrofuranyl)-L-alanyl-L-proline (Isomer B) [in the formula (I), R1 =--(CH2)5CH3, R2 =H, R3 =CH3, R4 and R5 =--(CH2)3 --, R6 =H (Compound 14)].

Provenance & Evidence