Cyclopropylamine → HCID 13883398, compound

HRID 2352447Notes

Reaction equation

HRID 2352447 reaction equation
[F:1][C:2]1[N:7]=[C:6](F)[CH:5]=[C:4]([C:9]([F:12])([F:11])[F:10])[N:3]=1.[CH:13]1([NH2:16])[CH2:15][CH2:14]1>>[CH:13]1([NH:16][C:6]2[CH:5]=[C:4]([C:9]([F:12])([F:11])[F:10])[N:3]=[C:2]([F:1])[N:7]=2)[CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 13883397HCID 13883397, compound

Product 1

HCID 13883398HCID 13883398, compound

Procedure

If, for example, 2,4-difluoro-6-trifluoromethylpyrimidine and cyclopropylamine are used as starting materials and the 4-cyclopropylamino-2-fluoro-6-trifluoromethylpyrimidine thereby formed is reacted with 3-methoxypropylamine, then the course of the reaction can be summarized by the following reaction scheme: ##STR7##

Sources & evidence

ORD record
ord-67d3833afb684566850347cae52ce2df
Source dataset
uspto-grants-1989_10
Patent number
US04877443

Reaction notes

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