1,4-Dioxane → HCID 54111985, compound

Participants

Reaction Steps

41.6 g of 6-nitro-2-styrylquinoline were added in portions to a mixture containing 69 g of reduced iron, 6.9 g of aluminum chloride, 450 ml of dioxane, and 90 ml of water with heating under reflux. After heating under reflux for a further 5 hours, the solid was filtered using a Nutsche filter in which sellaite is laid. The filtrate was condensed, 130 ml of ethyl acetate were added thereto, and the deposited crystals were filtered. 28 g (74% of the theoretical yield) of the 6 -amino-2-styrylquinoline crystals were produced.

Provenance & Evidence