Methyl iodide → HCID 19843279, compound

Participants

Reaction Steps

A mixture of ethyl 2-methyl-7-hydroxythieno[3,2-b]pyridine-6-carboxylate (21 g), potassium carbonate (12.2 g) and dry dimethylformamide (750 ml) was stirred at ambient temperature and iodomethane (6 ml) added. The mixture was stirred at ambient temperature for approximately 3.5 hours, then at 60° for 2 hours. The solvent was removed under reduced pressure to give a residue which on treatment with water (300 ml) gave the novel compound ethyl 2,4-dimethyl-7-oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxylate, m.p. 143°-144°.

Provenance & Evidence