1-Bromopropane → HCID 67842251, compound

HRID 2352545Notes

Reaction equation

[ClH:1].[F:2][C:3]1[CH:8]=[CH:7][C:6]([C@@H:9]2[CH2:14][CH2:13][NH:12][CH2:11][C@H:10]2[CH2:15][O:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]([CH3:26])([CH3:25])[CH3:24])=[CH:19][CH:18]=2)=[CH:5][CH:4]=1.[CH2:27](Br)[CH2:28][CH3:29]>>[ClH:1].[CH2:27]([N:12]1[CH2:13][CH2:14][C@@H:9]([C:6]2[CH:7]=[CH:8][C:3]([F:2])=[CH:4][CH:5]=2)[C@H:10]([CH2:15][O:16][C:17]2[CH:18]=[CH:19][C:20]([C:23]([CH3:26])([CH3:25])[CH3:24])=[CH:21][CH:22]=2)[CH2:11]1)[CH2:28][CH3:29]

Participants

Reactant 2

HCID 78401-Bromopropane

HCID 67842104HCID 67842104, compound

Product 1

HCID 67842251HCID 67842251, compound

Procedure

trans-1-propyl-4-(4-fluorophenyl)-3-(4-t-butylphenoxymethyl)-piperidine hydrochloride M.p. 221.1° C. was prepared exactly as described in example 1 from trans-4-(4-fluorophenyl)-3-(4-t-butylphenoxymethyl)-piperidine hydrochloride and propyl bromide by refluxing for 96 hours.

Workup

temperatureby refluxing for 96 hours

Sources & evidence

ORD record: ord-eb047d64ff7044358b0be41bb60bb999
Source dataset: uspto-grants-1989_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04877799

Reaction notes

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