Lawesson's reagent → HCID 19843389, compound

Participants

Reaction Steps

A mixture of the N-propyl-N-[2-(4-chlorophenoxy)ethyl]thiazole-5-carboxamide (0.9 g, 3 mmol) obtained in Example 2B and Lawesson's Reagent (2,4-bis(4-methoxyphenyl)-1,3-dithia-2,4-diphosphetane-2,4-disulphide, 1.2g, 3 mmol) was refluxed for 20 hours and then cooled to room temperature. Water (100 ml) was added and the residue was extracted into ether (2×200 ml). The combined organic extract was washed with saturated sodium chloride solution (50 ml) and dried over magnesium sulphate. Evaporation of the solvent left an oil which, after flash chromatography on silica gel using 1:1 ethyl acetate: petroleum ether as the eluant, yielded the desired product as a yellow oil (0.75 g), M+ found: 340

Provenance & Evidence