Acetic Acid → HCID 14071983, compound

Participants

Reaction Steps

A solution of 300 mg of 5-hydroxy-4-methoxy-methyl-β-carboline-3-carboxylic acid ethyl ester in 3 ml of dry dimethyl sulfoxide is combined with 155 mg of K2CO3 and stirred under nitrogen at room temperature for 30 minutes. After adding 0.2 ml of 2-chloropyrazine, the mixture is agitated for 6 hours at 95° C., then poured into 1N acetic acid and extracted with ethyl acetate. Purification over silica gel yields 242 mg (64%), mp 130°-131° C. (diethyl ether).

Provenance & Evidence