HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → 2-Methylbutyl 4'-hydroxybiphenyl-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 4'-Hydroxy-4-biphenylcarboxylic acid | HCID 301556 | — |
| Reactant | (S)-2-methyl-1-butanol | HCID 2723602 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 2-Methylbutyl 4'-hydroxybiphenyl-4-carboxylate | HCID 13907537 | 98% |
Reaction Steps
93 m mol (20 g) of 4'-hydroxybiphenyl-4-carboxylic acid and 467 m mol (41 g) of (S)-(-)-2-methylbutanol were refluxed for 25 hours in 150 ml of benzene in the presence of 2 ml of Conc. sulfuric acid while removing water. The resulting reaction solution was concentrated and was recrystallized from a toluene-hexane solvent mixture to obtain 26.0 g of the objective ester (m.p. 116-117.8° C., [α]D23 =+4.35° (CHCl3)). (Yield: 98 %).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04877858 |
| Source dataset | uspto-grants-1989_10 |
| ORD ID | ord-9e4a4c00644c40c789c5687a8ff48b2c |
| Source note | uspto-grants-1989_10 |