4-Hydroxybenzoic Acid → Benzoic acid, 4-hydroxy-, 2-methylbutyl ester

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Reaction Steps

4.0 g of p-hydroxybenzoic acid and 12.5 g of 2-methylbutanol were refluxed for 6 hours in toluene in the presence of sulfuric acid while removing water. The resulting reaction solution was then washed with water to remove sulfuric acid. The organic phase was then dried, concentrated, and purified by column chromatography to obtain 5.0 g of the objective ester (liquid, at room temperature, [α]D23 =+4.9° (CHCl3)). (Yield: 83%).

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