2-Chloroethanol → HCID 14881117, compound

HRID 2352593Notes

Reaction equation

HRID 2352593 reaction equation
[CH2:1](Cl)[CH2:2][OH:3].[OH:5][C:6]1[C:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[N:10][C:9]([CH3:18])=[C:8]([CH3:19])[N:7]=1.[OH-].[Na+].O>C(O)(C)(C)C>[OH:3][CH2:2][CH2:1][N:7]1[C:8]([CH3:19])=[C:9]([CH3:18])[N:10]=[C:11]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:6]1=[O:5]

Participants

6

Reactant 4

HCID 342-ChloroethanolHCID 962WaterHCID 14798Sodium HydroxideHCID 178433435HCID 178433435, compound

Product 1

HCID 14881117HCID 14881117, compoundYield 71.6%

Reagents, catalysts & solvents 1

HCID 6386tert-ButanolSolvent

Conditions

Temperature
60 °C

Procedure

Ethylene chlorohydrin (20.2 g, 0.25M) was added to a solution of 2-hydroxy-3-phenyl-5,6-dimethyl-pyrazine (10.0 g, 50 mM) and 5N NaOH (50 ml) in t-butanol (150 ml), and stirred at 60° C. for 2.5 hours. Water was added to the reaction mixture, the mixture extracted with chloroform, and the extract dried with anhydrous sodium sulfate and concentrated in vacuo. The residue was charged on a column of silica-gel (C-200, 130 g) packed with chloroform and eluted with chloroform-methanol (100:1) to obtain compound 109 (8.73 g, yield: 71.5%).

Workup

  1. extractionthe mixture extracted with chloroform
  2. dry with materialthe extract dried with anhydrous sodium sulfate
  3. concentrationconcentrated in vacuo
  4. additionThe residue was charged on a column of silica-gel (C-200, 130 g)
  5. washeluted with chloroform-methanol (100:1)

Sources & evidence

ORD record
ord-c4c0e20fd2344cfd8ad256a27fae8e44
Source dataset
uspto-grants-1989_10
Patent number
US04877875

Reaction notes

Loading…