Dimethyl Sulfate → HCID 178503891, compound

Participants

Reaction Steps

A mixture of 32 g (0.1 mol) of 4-cyanophenyl isothiocyanate and of 12.8 g (0.2 mol) of monosodium cyanamide in 100 cm3 of absolute ethanol is maintained for 2 hours at boiling point. After cooling, the precipitate obtained is filtered and washed with 200 cm3 of absolute ethanol. The solid is then placed in suspension in a solution of dimethyl sulfate (25 g, 0.2 mol) in 500 cm3 of ethanol; the mixture is heated for two hours at boiling point. The final precipitate is filtered, washed with 2×100 cm3 of water and with 2×100 cm3 of ethanol, then is dried in vacuo. 32.8 g (yield 70%) of N-(4-cyanophenyl)-N'-cyano-S-methylisothiourea are obtained: ##STR9## which is a white solid, whose melting point is 225°-230° C.

Provenance & Evidence