Ethanol → HCID 56637441, compound

Participants

Reaction Steps

A mixture of 5 g (0.031 mol) of 4-cyanophenyl isothiocyanate, of 6.3 g (0.04 mol) of benzenesulfonamide in 50 cm3 of acetone and of 1.6 g (0.04 mol) of sodium hydroxide in 3 cm3 of water is maintained for two hours at room temperature. The precipitate obtained is filtered, washed with acetone and ethyl ether (2×20 cm3). The final solid (9 g; yield 94%) is then placed in 50 cm3 of 95% ethanol containing 2.75 cm3 (0.044 mol) of methyl iodide. After 24 hours at room temperature the solution is concentrated to dryness and the residue is washed with ethyl ether (3×20 cm3) and dried in vacuo. 8.5 g (yield 80%) of N-(4-cyanophenyl)-N'-phenylsulfonyl-S-methylisothiourea (melting point 150° C.) is obtained: ##STR23##

Provenance & Evidence