Water → HCID 54091611, compound

Participants

Reaction Steps

To a slurry of sodium hydride (125 mg, 5.2 mmol) in 5 ml of THF and 2 ml of HMPA under N2 is added dimethylcarbamoyl chloride (0.37 ml, 430 mg, 4.0 mmol). The slurry is cooled in an ice bath and 3-fluoro-3-hexylthio-2-propen-1-ol (450 mg, 2.34 mmol) is added gradually. After 1 hour, the mixture is cautiously poured into water, extracted with ether and stripped to give 3-fluoro-3-hexylthio-2-propenyl dimethylcarbamate.

Provenance & Evidence