Sodium Hydroxide → (2-t-Pentyloxycarbonylamino-1,3-thiazol-4-yl)glyoxylic acid

HRID 2352723Notes

Reaction equation

HRID 2352723 reaction equation
[C:1]([O:6][C:7]([NH:9][C:10]1[S:11][CH:12]=[C:13]([C:15](=[O:21])[C:16]([O:18]CC)=[O:17])[N:14]=1)=[O:8])([CH2:4][CH3:5])([CH3:3])[CH3:2].[OH-].[Na+]>O>[C:1]([O:6][C:7]([NH:9][C:10]1[S:11][CH:12]=[C:13]([C:15](=[O:21])[C:16]([OH:18])=[O:17])[N:14]=1)=[O:8])([CH2:4][CH3:5])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 19978748Ethyl 2-(2-t-pentyloxycarbonylamino-1,3-thiazol-4-yl)glyoxylate

Product 1

HCID 19978737(2-t-Pentyloxycarbonylamino-1,3-thiazol-4-yl)glyoxylic acidYield 68.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Ethyl 2-(2-t-pentyloxycarbonylamino-1,3-thiazol-4-yl)glyoxylate (2.8 g.) and a solution of sodium hydroxide (0.54 g.) in water (20 ml.) were treated according to a similar manner to that of Preparation 6-5) to give brown powder of 2-(2-t-pentyloxycarbonylamino-1,3-thiazol-4-yl)glyoxylic acid (1.75 g.).

Workup

  1. customof Preparation 6-5)

Sources & evidence

ORD record
ord-35f2ee0958ec4aa296ea65d196495936
Source dataset
uspto-grants-1989_10
Patent number
US04877873

Reaction notes

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