反应详情

A stirred solution of the crude 2-phenyl-6-methyl-pyridine-N-oxide (5.2 g, 28.5 mmol) in Ac2O (25 ml) was heated at reflux temperature for 2 hrs. The Ac2O was removed with the aid of an oil pump (10 mm) at 40° C. to yield a red oil which was purified by flash chromatography over silica gel with Et2O/petroleum benzine=1/1 as the eluent and yielded 2-phenyl-6-(acetoxymethyl)-pyridine (4.6 g, 70%) as an oil.

1. temperatureat reflux temperature for 2 hrs
2. customThe Ac2O was removed with the aid of an oil pump (10 mm) at 40° C.
3. customto yield a red oil which
4. customwas purified by flash chromatography over silica gel with Et2O/petroleum benzine=1/1 as the eluent